Depression Drug Adverse Reactions Including Body Weight, BP Fluctuations Range Depending on Medication

• An comprehensive latest research determined that the unwanted effects of depression drugs differ considerably by drug.
• Certain pharmaceuticals led to reduced body weight, while different drugs resulted in increased body weight.
• Cardiac rhythm and BP additionally differed markedly between medications.
• Individuals encountering ongoing, severe, or worrisome unwanted effects must speak with a physician.

Latest research has revealed that depression drug adverse reactions may be more diverse than previously thought.

This comprehensive research, published on the 21st of October, analyzed the impact of depression treatments on over 58,000 individuals within the first eight weeks of starting therapy.

The scientists studied 151 investigations of 30 medications commonly prescribed to manage major depression. While not everyone experiences side effects, certain of the most frequent recorded in the study were fluctuations in weight, arterial pressure, and metabolic parameters.

There were notable variations between antidepressant medications. For instance, an two-month treatment period of agomelatine was associated with an typical reduction in body weight of approximately 2.4 kilograms (approximately 5.3 lbs), whereas another drug patients added nearly 2 kg in the equivalent period.

Furthermore, significant changes in heart function: one antidepressant often would reduce heart rate, whereas another medication increased it, causing a disparity of around 21 heartbeats per minute between the two drugs. BP differed as well, with an 11 millimeters of mercury difference seen among one drug and doxepin.

Healthcare professionals observed that the research's findings are not novel or unexpected to psychiatrists.

"We've long known that various antidepressant medications differ in their impacts on weight, arterial pressure, and further metabolic measures," one expert stated.

"However, what is remarkable about this study is the thorough, comparison-based measurement of these disparities throughout a wide spectrum of physiological parameters utilizing findings from more than 58,000 participants," this expert noted.

The investigation delivers comprehensive proof of the extent of unwanted effects, several of which are more prevalent than other effects. Typical antidepressant medication unwanted effects may comprise:

• stomach problems (sickness, loose stools, irregularity)
• sexual problems (decreased libido, orgasmic dysfunction)
• body weight fluctuations (gain or decrease, based on the agent)
• sleep problems (sleeplessness or drowsiness)
• mouth dryness, perspiration, head pain

At the same time, less common but therapeutically relevant adverse reactions may comprise:

• elevations in arterial pressure or cardiac rhythm (notably with serotonin-norepinephrine reuptake inhibitors and certain tricyclic antidepressants)
• hyponatremia (particularly in elderly individuals, with selective serotonin reuptake inhibitors and SNRIs)
• increased liver enzymes
• Corrected QT interval extension (risk of abnormal heart rhythm, especially with one medication and certain tricyclic antidepressants)
• diminished feelings or indifference

"One thing to note in this context is that there are multiple different types of antidepressants, which lead to the different adverse medication effects," another specialist explained.

"Additionally, antidepressant medications can impact each person distinctly, and adverse side effects can vary depending on the specific medication, dosage, and individual elements including metabolic rate or simultaneous health issues."

While some adverse reactions, like variations in sleep, appetite, or energy levels, are reasonably common and frequently enhance with time, different reactions may be less common or longer-lasting.

Depression drug unwanted effects may vary in seriousness, which could justify a adjustment in your medication.

"A adjustment in depression drug may be appropriate if the patient encounters ongoing or unbearable adverse reactions that do not improve with passing days or supportive measures," a expert stated.

"Furthermore, if there is an development of new medical conditions that may be worsened by the existing treatment, for example high blood pressure, irregular heartbeat, or considerable mass addition."

You may additionally consider speaking with your doctor regarding any absence of meaningful progress in depressive or anxiety signs after an appropriate evaluation duration. An sufficient testing period is generally 4–8 weeks at a therapeutic amount.

Individual inclination is furthermore crucial. Certain people may prefer to evade certain unwanted effects, like sexual dysfunction or {weight gain|increased body weight|mass addition